The Buffalo Bills will look to remain unbeaten Sunday when they host the New England Patriots in their first AFC East matchup of the season. Kickoff is set for 1 p.m. at Highmark Stadium, with the game airing on CBS.
Buffalo enters Week 4 at 3-0 after a 24-16 win over the Los Angeles Chargers, while New England is 1-2 following a 35-6 loss to the Jacksonville Jaguars.
The stakes are already significant in the division despite this being the first meeting. A Patriots loss would drop New England three games behind Buffalo and give the Bills the early head-to-head advantage in the AFC East.
The matchup also brings back memories of last season. Buffalo was 4-0 and New England was 2-2 when the Patriots visited Buffalo in 2025, but New England won 23-20. That victory started a 10-game winning streak for the Patriots, who ultimately ended Buffalo’s five-year run atop the AFC East.
A victory would give the Bills their second straight 4-0 start to the season.
GAME WEEK LINKS
- Top Storylines for Bills vs. Patriots | Week 4 (buffalobills.com)
- Patriots arrive desperate as Bills try to avoid 2025 repeat (democratandchronicle.com)
- Bills vs. Patriots: 5 things to watch for during Week 4 (billswire.usatoday.com)
- Buffalo Bills vs. New England Patriots; Movable object vs. stoppable force (buffalorumblings.com)
- What Bills fans can expect at Highmark Stadium for Week 4 vs. Patriots (buffalobills.com)
- ‘A hard team to game plan for’ | Bills prepare for the New England Patriots after uneven Week 3 outing (buffalobills.com)
- Everything is going wrong for New England Patriots ahead of Buffalo Bills matchup (syracuse.com)
- Patriots blitz more than almost any NFL team. Josh Allen is waiting. (democratandchronicle.com)
- Buffalo Bills vs. Patriots: Josh Allen rivalry history (buffalorumblings.com)
- Where Josh Allen, James Cook, Bills players rank among NFL leaders ahead of Week 4 (billswire.usatoday.com)
- Experts release early Patriots vs. Bills predictions as Josh Allen and Buffalo seek 4-0 start (syracuse.com)
PRESS CONFERENCES
MEDIA
Week 4 – Bills vs. Patriots:
— Buffalo Bills PR (@BuffaloBillsPR) September 29, 2026
📍 Highmark Stadium
🕓 1 PM (Sunday, October 4)
📺 CBS (Ian Eagle, Ross Tucker & Evan Washburn)
📻 97 Rock (Chris Brown, Eric Wood & Steve Tasker) / ESPN Radio (Steve Levy, Max Starks & Dan Graziano)#LeadingTheCharge pic.twitter.com/8JCRZGFZMw
See you Sunday, @natashabdnfield 😊
We’re honored to celebrate those who continue to inspire others in the fight against cancer during a special halftime performance this weekend: https://t.co/18NFqVcsHY pic.twitter.com/9wYsdr1D9A— Buffalo Bills (@BuffaloBills) October 1, 2026Also readORANGE GAME WEEK: Syracuse football returns from bye week for road matchup against UConn (preview)
Kyle leads sports coverage and hosts the Concrete Jungle podcast. Have a lead or question? Send it to kyle@fingerlakes1.com.