The Syracuse Mets fell to the Buffalo Bisons, 3-1, on Friday night at NBT Bank Stadium.
Jose Butto made his Triple-A debut for Syracuse and surrendered three runs over five innings.
Francisco Alvarez drove in the lone run for the Mets with an RBI single in the bottom of the eighth.
Logan Warmoth, Stevie Berman, and Nathan Lukes collected RBIs for Buffalo.
Trey Cobb, Stephen Nogosek, and Alex Claudio had scoreless outings.
The week-long series will continue on Saturday at 6:35 p.m.