The New York Yankees (81-78) had a chance to sweep the Toronto Blue Jays (88-71) on Thursday night but were blanked 6-0.
Luke Weaver surrendered two runs over four innings, Greg Weissert allowed one, and Zach McAllister gave up three.
New York’s offense collected seven hits, going 0-for-5 with runners in scoring position and leaving eight on base.
Yoendrys Gómez tossed two scoreless frames in his Major League debut.
The Yankees will begin their final series of the season on Friday in Kansas City when they take on the Royals at 8:10 p.m.