The New York Yankees (36-17) began a season-long 10-day, nine-game road trip on Friday night in San Diego and rolled past the Padres (27-27), 8-0, behind a four-homer game.
Juan Soto and Aaron Judge hit back-to-back home runs, while Giancarlo Stanton and Gleyber Torres also went deep.
Carlos Rodón tossed six shutout innings while allowing just three hits. Dennis Santana fired two scoreless before Yoendrys Gómez struck out the side in the ninth in his second big-league game.
The Yankees look to improve to a season-high 20 games over .500 and win another series on Saturday at 9:40 p.m. with Marcus Stroman on the bump.