The Buffalo Sabres opened up their five-game road trip with a 3-2 loss to the New York Rangers at Madison Square Garden on Tuesday.
Sam Reinhart and Tobias Rieder scored for the Sabres and Carter Hutton stopped 16 of 19 shots.
Pavel Buchnevich, Alexis Lafrenière and Chris Kreider tallied for the Rangers. Igor Shesterkin made 21 saves in net.
The Sabres are 1-1-1 against the Rangers this season. The clubs will meet again on March 22 in New York.
Buffalo is 0-3-1 over its last four games.